Ajinomoto

Last updated January 31, 2026

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Flow microreactor protein refolding: AjinomotoRecent Research Landscape

Protein misfolding and aggregation during large-scale production lead to low yields of bioactive substances. These innovations utilize controlled flow microreactors to precisely manage the kinetic environment for efficient supramolecular assembly and refolding.

What technical problems is Ajinomoto addressing in Flow microreactor protein refolding?

Protein aggregation during renaturation

(7)evidences

Spontaneous misfolding and non-specific binding prevent the formation of functional supramolecular structures. Preventing these failures ensures high yields of bioactive encapsulated substances.

Proteolytic degradation during secretion

(6)evidences

Endogenous protease activity and inefficient extracellular transport limit the yield of intact recombinant proteins. Reducing these degradation pathways ensures the stability and recovery of complex or unnatural proteins.