Ajinomoto

Last updated January 31, 2026

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Regioselective enzymatic sulfation and epimerization: AjinomotoRecent Research Landscape

Inefficient chemical sulfation of complex glycans leads to low yields and poor structural specificity. These engineered biocatalysts enable precise site-specific modification of heparin precursors to ensure therapeutic potency.

What technical problems is Ajinomoto addressing in Regioselective enzymatic sulfation and epimerization?

Low glycosaminoglycan structural uniformity

(3)evidences

Inconsistent placement of sulfate groups and incorrect uronic acid stereochemistry lead to non-functional heparin analogs. Precise structural control ensures biological activity and reduces byproduct formation.

Low biocatalytic synthesis efficiency

(3)evidences

Inefficient conversion rates and poor regioselectivity in enzymatic processes limit the industrial production of functionalized amino acids. Improving these yields reduces waste and lowers production costs for high-purity target substances.