Ajinomoto

Last updated January 31, 2026

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Talaromyces cellulolyticus pep4 protease inhibition: AjinomotoRecent Research Landscape

Proteolytic degradation and inefficient translocation limit the yield of complex recombinant proteins. These modifications optimize secretion machinery and silence endogenous proteases to ensure high-titer production of functional proteins.

What technical problems is Ajinomoto addressing in Talaromyces cellulolyticus pep4 protease inhibition?

Extracellular protein degradation

(8)evidences

Endogenous proteases like pep4 break down target proteins during secretion. Preventing this degradation increases the yield and integrity of high-value recombinant products.

Proteolytic degradation of secreted proteins

(6)evidences

Endogenous protease activity breaks down target proteins during production. Eliminating this degradation increases the yield and structural integrity of secreted bioactive substances.