Amorepacific

Last updated January 31, 2026

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Chiral resolubilization and crystallization control: AmorepacificRecent Research Landscape

Uncontrolled crystallization of (R)-N-[1-(3,5-difluoro-4-methanesulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethylpyridin-3-yl)-acrylamide reduces bioavailability and shelf stability. This lever stabilizes the amorphous or dissolved state to ensure consistent therapeutic dosing.

What technical problems is Amorepacific addressing in Chiral resolubilization and crystallization control?

Uncontrolled stereoisomer crystallization

(1)evidences

Spontaneous crystallization of the active ingredient leads to poor bioavailability and inconsistent dosing. Preventing this degradation ensures therapeutic efficacy and shelf-life stability.

Poor aqueous drug solubility

(1)evidences

Inconsistent chiral separation and low optical purity in benzoic acid amide synthesis. Achieving high enantiomeric excess ensures pharmacological efficacy and reduces toxicological risk from unwanted isomers.