Amorepacific

Last updated January 31, 2026

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Physically crosslinked hyaluronic acid networks: AmorepacificRecent Research Landscape

Standard hyaluronic acid fillers degrade rapidly and lack lipid-barrier integration, leading to poor clinical longevity. Covalent ceramide bonding engineers a dual-function structural network that stabilizes the gel against enzymatic breakdown while restoring skin barrier function.

What technical problems is Amorepacific addressing in Physically crosslinked hyaluronic acid networks?

Poor active ingredient stability

(5)evidences

Hyaluronic acid is susceptible to fast metabolic breakdown by hyaluronidases in vivo. Conjugating hydrophobic ceramides and creating microparticle structures increases resistance to enzymatic cleavage to extend therapeutic residence time.

Rapid bioactive substance degradation

(1)evidences

Native hyaluronic acid possesses a short half-life due to hyaluronidase activity. Extending residence time in dermal layers prevents premature loss of therapeutic effect.