Centella and Chrysanthemum extracts often fail to maintain consistent collagen synthesis rates without complex multi-step fermentation stabilization.

Marine-derived Micrococcus and Neocamarosporium strains exhibit unpredictable metabolite production in standard culture mediums, hindering skin-whitening efficacy.

Lactobacillus plantarum strains frequently lose the ability to activate epidermal keratinocytes when pH levels fluctuate in topical formulations.

Peptide complexes in fermented rice and sake lees degrade rapidly under oxidative stress, neutralizing their anti-inflammatory and skin-regenerative properties.