Inconsistent substitution patterns and poor control over trifluoromethyl group placement during synthesis. Achieving precise regiochemical control reduces byproduct formation and increases chemical purity.

Uncontrolled spatial arrangement of atoms during synthesis leads to inactive or harmful isomers. Achieving high enantiomeric or diastereomeric excess ensures biological efficacy and reduces chemical waste.

Chemical synthesis often produces racemic mixtures or insufficient ratios of the desired isomer. Achieving high optical purity is critical for the biological efficacy and safety of chiral compounds.

Inefficient formation of specific isomers during the synthesis of pyridazines and pyrazoles. Precise control over substituent placement ensures the potency of herbicidal active ingredients.