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Last updated January 31, 2026
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Chlorothiazolyl ethanone synthesis pathway: BASFRecent Research Landscape

Inefficient multi-step synthesis of heterocyclic intermediates increases manufacturing costs and impurity profiles. This lever controls the regioselective chlorination and acylation required to produce high-purity 2-chlorothiazol-5-yl derivatives.

What technical problems is BASF addressing in Chlorothiazolyl ethanone synthesis pathway?

Low intermediate synthesis yields

(13)evidences

Inefficient conversion rates and poor selectivity in multi-step organic synthesis. Improving yield reduces waste and lowers production costs for complex intermediates.

Low enantiomeric purity

(11)evidences

Chemical synthesis pathways for complex thiazolyl compounds often produce racemic mixtures or insufficient optical enrichment. Achieving high enantiomeric excess is critical for the biological efficacy and regulatory compliance of chiral agrochemicals or pharmaceuticals.

Low regioselectivity in heterocyclic halogenation

(9)evidences

Inefficient chemical conversion during the formation of complex nitrogen and sulfur heterocycles. Improving reaction efficiency reduces waste and lowers production costs for active ingredients.

Inefficient amide bond formation

(8)evidences

Conventional synthetic routes for polyfluorinated and substituted aromatic carboxamides suffer from low yields and poor regioselectivity. Overcoming these limitations enables the production of complex pharmaceutical intermediates with higher purity and reduced waste.