Chromanol and naphthoquinone ring substitution: BASFRecent Research Landscape
Inefficient chemical yields and low purity in vitamin E and K analogues increase manufacturing costs. These innovations control the regioselective condensation and cyclization steps to ensure high-potency derivative production.
What technical problems is BASF addressing in Chromanol and naphthoquinone ring substitution?
Low synthetic yield
(10)evidences
Low selectivity and degradation during the formation of volatile isoprenoid precursors. Stabilizing these intermediates ensures higher yields of downstream fragrance and vitamin precursors.
Low synthetic yield
(9)evidences
Inefficient chemical conversion pathways for complex bicyclic and quinone structures. Improving yield reduces waste and manufacturing costs for bioactive precursors.
Low enantiomeric purity
(6)evidences
Uncontrolled reduction of multiple functional groups leads to poor product purity. Achieving high selectivity prevents the formation of unwanted side-products in complex unsaturated molecules.