Inefficient conversion rates and poor selectivity in multi-step organic synthesis. Improving yield reduces waste and lowers production costs for specialized chemical intermediates.

Inefficient production of single-isomer bioactive molecules leads to reduced biological efficacy and unwanted side effects. Achieving high optical enrichment ensures maximum potency and regulatory compliance for agrochemical and pharmaceutical applications.

Standard carbonylation and amidation methods often fail or degrade in the presence of highly electronegative polyfluorinated groups or sensitive hydroxycarbamimidoyl moieties. Overcoming these chemical incompatibilities allows for the synthesis of complex bioactive scaffolds that were previously inaccessible.

Uncontrolled substitution patterns and poor structural specificity during ring formation. Achieving high isomeric purity reduces costly downstream separation and purification steps.