BASF

Last updated January 31, 2026

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Engineered amylase and mannanase variants: BASFRecent Research Landscape

Enzyme denaturation in liquid states leads to rapid loss of catalytic activity and product shelf-life failure. These innovations employ specific chemical stabilizers and co-solvents to maintain the structural integrity of the hydrolase fold during storage.

What technical problems is BASF addressing in Engineered amylase and mannanase variants?

Enzyme storage instability

(19)evidences

Hydrolases in liquid states suffer from rapid loss of catalytic activity over time. Preventing this instability ensures product shelf-life and consistent cleaning performance.

Low dietary phosphorus bioavailability

(3)evidences

Enzymatic degradation during high-temperature processing and acidic digestion. Maintaining structural integrity ensures bio-availability and consistent catalytic activity in harsh environments.

Enzymatic instability in harsh conditions

(3)evidences

Standard mannanase enzymes denature or lose catalytic activity in high pH environments typical of industrial formulations. Maintaining structural integrity across a broad pH range prevents performance loss in detergents and cleaners.