Repeated exposure to single-site fungicides leads to decreased efficacy and resistant populations. Combining active ingredients with different modes of action prevents the survival of resistant strains and extends the commercial lifespan of the treatment.

Existing fungicidal classes face declining efficacy due to evolving pathogen mutations. Developing novel chemical scaffolds like quinolines and dihydropyrrolotriazines overcomes cross-resistance and restores crop protection.

Fungal pathogens develop resistance to single-site inhibitors and existing treatments suffer from rapid degradation. Addressing these limitations ensures sustained crop protection and prevents chemical efficacy loss.

Fungal pathogens evolve resistance to single-mode fungicides, leading to uncontrolled outbreaks and yield degradation. Combining active ingredients overcomes efficacy gaps and prevents total crop failure.