BASF

Last updated January 31, 2026

319

Innovation Areas

13,244

Inventors

154

Collaborations

Regioselective catalytic heterocyclic halogenation: BASFRecent Research Landscape

Inefficient synthesis of substituted pyridazines and pyrazoles leads to high precursor waste and low isomeric purity. These innovations utilize specific catalytic hydrogenation pathways to ensure high-yield regioselective formation of nitrogen-containing rings.

What technical problems is BASF addressing in Regioselective catalytic heterocyclic halogenation?

Low regioselectivity in halogenation

(17)evidences

Uncontrolled substitution patterns lead to isomeric impurities and low product purity. Achieving precise site-specific functionalization reduces waste and downstream separation costs.

Low regiochemical reaction specificity

(16)evidences

Uncontrolled substitution patterns in complex aromatic and heterocyclic scaffolds lead to poor isomeric purity. Achieving precise site-specific halogenation or amidation prevents yield loss and costly separation of structural isomers.

Low enantiomeric purity

(9)evidences

Inconsistent chiral distribution in heterocyclic synthesis leads to suboptimal chemical efficacy. Achieving high optical purity ensures precise biological activity and reduces unwanted side effects.