The keywords focus on the preparation of specific chiral isomers and enantiomers. Solving the lack of optical purity prevents the formation of inactive or toxic stereoisomers in pharmaceutical synthesis.

Direct conversion of polyfluoroalkyl alcohols to amines and selective halogenated aniline synthesis are historically hindered by low yields and harsh conditions. Overcoming these synthetic bottlenecks enables more cost-effective production of complex fluorinated building blocks.

Difficulty in isolating high-purity fluorinated solvents and specific stereoisomeric intermediates from complex reaction mixtures. Improving recovery and purification reduces waste and lowers production costs for chiral precursors.

Inefficient conversion rates and poor regioselectivity in complex heterocyclic coupling. Improving yield reduces waste and manufacturing costs for specialized agrochemical intermediates.