Substitution patterns in polyfluorinated and chloro-fluoro compounds often result in unwanted isomers or poor yields. Achieving precise positional control during synthesis prevents material waste and costly separation steps.

Chemical synthesis often produces racemic mixtures where only one isomer is biologically active or safe. Improving chiral separation prevents reduced therapeutic efficacy and off-target toxicity.

The presence of unwanted stereoisomers and chemical impurities in pharmaceutical intermediates. Achieving high optical purity ensures drug safety and regulatory compliance.