Inadequate activation of immune pathways limits the efficacy of treatments for complex pathologies. Enhancing specific signaling nodes overcomes biological resistance to monotherapy.

Insufficient activation of the guanylate cyclase pathway leads to systemic vascular dysfunction. Restoring this signaling addresses underlying causes of heart failure and pulmonary hypertension.

Excessive or inappropriate blood clotting leads to life-threatening vascular blockages. Preventing these events without causing systemic bleeding improves patient safety and survival.

Acute brain tissue death and subsequent functional impairment following vascular occlusion. Preventing these deficits reduces long-term disability and mortality in stroke patients.