Bayer

Last updated January 31, 2026

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Substituted thiophenecarboxamide scaffold derivatives: BayerRecent Research Landscape

Bacterial resistance renders standard antibiotics ineffective, necessitating the engineering of specific heterocyclic carboxamide derivatives to inhibit pathogen growth. These synthetic intermediates provide a precise chemical lever for modulating antibacterial potency and metabolic stability.

What technical problems is Bayer addressing in Substituted thiophenecarboxamide scaffold derivatives?

Fungal pathogen resistance

(23)evidences

Fungal pathogens evolve resistance to single-agent treatments, leading to crop loss. Combining distinct chemical scaffolds overcomes existing resistance and prevents new resistance development.

Pathogenic fungal crop destruction

(17)evidences

Uncontrolled growth of pathogenic microorganisms leads to significant agricultural yield loss. Mitigating these biological threats prevents crop degradation and ensures food security.

Insufficient pharmacological potency

(15)evidences

Existing antibacterial treatments are increasingly ineffective due to evolving microbial defense mechanisms. Developing new chemical scaffolds overcomes therapeutic failure in treating infectious diseases.