Existing anthelmintic treatments suffer from reduced efficacy due to increasing drug resistance in parasitic nematode populations.

Targeted alpha therapies often fail to trigger a robust systemic immune response against diseased cells overexpressing specific mutated proteins.

Kinesin spindle protein inhibition is required to halt uncontrolled mitosis in cancer cells where standard cytotoxic delivery lacks sufficient tumor-associated selectivity.

Unstable conjugation between alpha-emitting radionuclides and targeting antibodies leads to premature isotope release and off-target radiation damage to healthy tissues.