CJ CheilJedang

Last updated January 21, 2026

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Bifunctional pyr operon transcriptional regulators: CJ CheilJedangRecent Research Landscape

Engineering specific enzymatic variants that combine transcriptional regulation with phosphoribosyltransferase activity. This controls the metabolic flux of the purine biosynthetic pathway to maximize 5'-inosine monophosphate yields.

What technical problems is CJ CheilJedang addressing in Bifunctional pyr operon transcriptional regulators?

Insufficient inosine monophosphate yield

(4)evidences

Low metabolic conversion rates and feedback inhibition limit the industrial production of inosine monophosphate. Overcoming these bottlenecks enables high-titer fermentation of flavor-enhancing nucleotides.

Inefficient nucleotide precursor conversion

(3)evidences

Natural transcriptional regulators and phosphoribosyltransferases are subject to strict feedback inhibition that limits industrial metabolite yields. Overcoming these regulatory bottlenecks allows for the hyper-production of 5'-inosinic acid and guanylic acid.