CJ CheilJedang

Last updated January 21, 2026

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Branched-chain aminotransferase mutant variants: CJ CheilJedangRecent Research Landscape

The technical lever is the site-specific mutagenesis of aminotransferase and prolyl isomerase enzymes. This controls the metabolic flux and substrate specificity for high-yield synthesis of branched-chain amino acids.

What technical problems is CJ CheilJedang addressing in Branched-chain aminotransferase mutant variants?

Insufficient metabolic flux

(11)evidences

Natural aminotransferase enzymes exhibit suboptimal metabolic flux and feedback inhibition during industrial fermentation. Overcoming these kinetic limitations is necessary to achieve commercially viable production titers of leucine and isoleucine.

Insufficient metabolic flux

(8)evidences

The keywords focus on variants of key enzymes like aspartate 1-decarboxylase and pyruvate dehydrogenase to overcome rate-limiting steps in biosynthesis. Solving this bottleneck increases the industrial yield and titer of specific amino acids.