CJ CheilJedang

Last updated January 21, 2026

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Corynebacterium glutamicum dahp synthase variants: CJ CheilJedangRecent Research Landscape

Engineering specific amino acid substitutions in the DAHP synthase enzyme to bypass feedback inhibition. This controls metabolic flux toward the shikimate pathway to maximize L-lysine yield.

What technical problems is CJ CheilJedang addressing in Corynebacterium glutamicum dahp synthase variants?

Insufficient metabolic flux bottleneck

(11)evidences

The cluster addresses the limited rate of precursor conversion in the shikimate pathway. Overcoming this bottleneck increases the yield and productivity of L-lysine biosynthesis.

Insufficient metabolic flux toward lysine

(10)evidences

The cluster addresses the metabolic bottleneck where wild-type strains cannot divert enough carbon precursors into the L-lysine biosynthetic pathway. Increasing this flux is critical for achieving industrially viable production yields.