Engineered microbial biosynthetic pathways: CJ CheilJedangRecent Research Landscape
Genetic modification of specific synthases and polynucleotide mutants to direct metabolic flux toward amino acids and dipeptides. This enables high-yield industrial fermentation of high-value nutritional compounds.
What technical problems is CJ CheilJedang addressing in Engineered microbial biosynthetic pathways?
Insufficient metabolic precursor flux
(12)evidences
The keywords focus on specific enzyme mutants and variants designed to overcome rate-limiting steps in amino acid synthesis. Increasing this flux is necessary to prevent low product titers in industrial fermentation.
Insufficient metabolic flux
(9)evidences
The cluster addresses the low natural yield and rate of amino acid synthesis in microorganisms. Overcoming metabolic bottlenecks and regulatory constraints allows for industrial-scale production of L-alanine and other amino acids.