CJ CheilJedang

Last updated January 21, 2026

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Engineered purine biosynthetic enzyme variants: CJ CheilJedangRecent Research Landscape

The technical control lever is the site-specific modification of glutamine-hydrolyzing enzymes and phytoene synthase variants. This engineering controls the metabolic flux and catalytic efficiency of the purine biosynthetic pathway to maximize 5'-guanosine monophosphate yield.

What technical problems is CJ CheilJedang addressing in Engineered purine biosynthetic enzyme variants?

Insufficient metabolic conversion efficiency

(4)evidences

The cluster addresses the low natural efficiency of converting intermediates like XMP into GMP. Overcoming this bottleneck enables commercially viable yields of high-value nucleotides.

Low metabolic flux bottleneck

(3)evidences

The cluster focuses on overcoming metabolic bottlenecks and feedback inhibition in purine biosynthesis pathways. Resolving these limitations enables the industrial-scale overproduction of high-value nucleotides like inosine monophosphate.