CJ CheilJedang

Last updated January 21, 2026

Innovation Areas

2,168

Inventors

Collaborations

Rhtc efflux protein overexpression: CJ CheilJedangRecent Research Landscape

Engineering the RHTC membrane transport protein to actively pump amino acids out of the cell. This bypasses feedback inhibition and increases extracellular yield of L-threonine and L-isoleucine.

What technical problems is CJ CheilJedang addressing in Rhtc efflux protein overexpression?

Intracellular amino acid toxicity

(11)evidences

High concentrations of synthesized L-threonine accumulate within the cell, leading to feedback inhibition and metabolic toxicity. Enhancing efflux through protein variants prevents growth inhibition and increases overall production yield.

Intracellular amino acid toxicity

(5)evidences

High concentrations of synthesized amino acids like L-threonine and L-isoleucine inhibit cell growth and trigger feedback inhibition. Facilitating efflux prevents metabolic stalling and cellular stress caused by excessive internal metabolite accumulation.