Yhhs and sulfhydrylase variants: CJ CheilJedangRecent Research Landscape
Engineering specific membrane transporters and sulfur-transfer enzymes to bypass metabolic bottlenecks. This enables high-titer microbial synthesis of sulfur-containing amino acids.
What technical problems is CJ CheilJedang addressing in Yhhs and sulfhydrylase variants?
Insufficient enzymatic biocatalytic productivity
(12)evidences
The wild-type YhhS and sulfhydrylase enzymes suffer from insufficient catalytic activity and low product yields for cysteine derivatives. Improving these variants overcomes the kinetic bottlenecks in industrial amino acid biosynthesis.