Colgate

Last updated January 31, 2026

Innovation Areas

915

Inventors

Collaborations

Bioactive oral formulation matrix: ColgateRecent Research Landscape

Chemical instability in aqueous oral formulations leads to the rapid oxidation of stannous ions and loss of therapeutic efficacy. This specific polyphosphate-pyrophosphate ratio stabilizes the metal ions to ensure long-term bioavailability and product shelf-life.

What technical problems is Colgate addressing in Bioactive oral formulation matrix?

Stannous fluoride chemical instability

(10)evidences

Bioactive fluoride ions react prematurely with standard abrasive agents, leading to loss of therapeutic efficacy. Preventing this degradation ensures long-term antimicrobial and anti-caries performance.

Stannous ion chemical instability

(3)evidences

Bioactive agents in the oral cavity are rapidly diluted or washed away by saliva and mechanical action. Improving retention ensures prolonged therapeutic contact time and efficacy.