Metal salts in oral environments suffer from rapid precipitation or degradation before reaching target tissues. Maintaining stability ensures therapeutic efficacy for desensitization or antimicrobial action.

Stannous fluoride undergoes rapid oxidation and precipitation in the presence of standard abrasive agents. Maintaining ionic bioavailability is essential for therapeutic efficacy in oral care.

Loss of tooth mineral density leads to structural failure and cavities. Preventing mineral dissolution maintains oral tissue integrity.