DSM-Firmenich

Last updated February 26, 2026

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Terpene synthase enzymatic pathway engineering: DSM-FirmenichLast 5 Years Research Landscape

Low natural yields of high-value fragrance and flavor molecules drive up sourcing costs and supply chain volatility. These innovations stabilize production through the precise genetic and enzymatic configuration of host cells to optimize metabolic flux toward specific sesquiterpene scaffolds.

What technical problems is DSM-Firmenich addressing in Terpene synthase enzymatic pathway engineering?

Insufficient metabolic flux to terpenes

(24)evidences

Natural biosynthetic pathways often exhibit low yields and poor conversion rates of precursor diphosphates into high-value sesquiterpenes. Overcoming these rate-limiting enzymatic steps is essential for industrial-scale biotransformation.

Insufficient sesquiterpene biosynthetic yields

(17)evidences

Natural metabolic pathways often suffer from low flux and poor conversion rates of pyrophosphate precursors into specific cyclic alcohols. Overcoming these metabolic bottlenecks allows for the industrial-scale production of high-value fragrance and flavor compounds.

Low terpene extraction yields

(13)evidences

Natural terpene concentrations in wood and biological sources are insufficient for industrial scale. Overcoming these yield bottlenecks allows for commercially viable biochemical production of high-value derivatives.