# Emerging targets in  targeted protein degradation (TPD) in cancers - PDAC, Gastric, MSS-CRC, NSCLC, Urothelial cancers

Topic radar · 346 documents · 2021-01-01–2026-09-02 · updated 2026-09-03

Canonical: https://slate.greyb.com/radar/emerging-targets-in-targeted-protein-degradation-tpd-in-cancers-pdac-gastric-mss-crc-nsclc-urothelial-cancers/innovations

## Overview


Treatment resistance from diverse KRAS mutations in solid tumors overcome through pan-KRAS protein degradation strategies



Oncogene persistence in cancer cells addressed via proteolysis targeting chimeras utilizing the ubiquitin proteasome system



Therapeutic limitations of undruggable oncoproteins resolved through targeted protein degradation via PROTAC-mediated elimination


## Areas

- TPD Platform & Ligase Innovation · 120 documents
- Oncogenic Driver Degraders · 95 documents
- Epigenetic & Transcriptional Regulators · 54 documents
- Proteostasis & Stress Response · 5 documents
- Cell Cycle & Signaling Modulators · 67 documents