Variations in skin resistance and manual application force lead to unpredictable penetration and dosage. Controlling these factors ensures precise delivery of active compounds into specific dermal layers.

Conventional cosmetic formulations often suffer from phase separation or chemical degradation of active ingredients before application. Preventing premature emulsion formation ensures ingredient integrity and long-term shelf stability.

Large molecular weight peptides and non-polymeric compounds cannot naturally penetrate the stratum corneum barrier. Overcoming this physical resistance allows for deep tissue delivery of active cosmetic ingredients.