Loreal

Last updated January 31, 2026

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Urea and salicylic acid synergists: LorealRecent Research Landscape

Skin barrier penetration is often limited by low solubility and instability of active ingredients, which is mitigated by high urea loading to enhance permeability. This approach reduces the need for invasive delivery methods while maximizing the potency of topical treatments.

What technical problems is Loreal addressing in Urea and salicylic acid synergists?

Visible skin aging progression

(23)evidences

Structural degradation and uneven texture of keratinous materials limit aesthetic and functional integrity. Addressing these surface defects restores barrier performance and visual uniformity.

Poor active ingredient penetration

(15)evidences

High concentrations of urea and salicylic acid often lead to crystallization or precipitation in standard vehicles. Overcoming these saturation barriers allows for more potent dermatological treatments without compromising formula stability.

Excessive cutaneous sebum production

(12)evidences

Insufficient lipid cohesion and structural instability in the stratum corneum. Restoring barrier function prevents transepidermal water loss and environmental sensitivity.