Suppression of T-cell activation and proliferation by kinase-mediated signaling pathways. Restoring immune surveillance enables the destruction of malignant cells.

Abnormal kinesin-5 (HSET) activity leads to centrosome clustering failure and mitotic instability in cancer cells. Inhibiting this mechanism restores normal apoptotic pathways in malignant tissues.

Unregulated enzymatic activity in metabolic and signaling pathways leads to pathological cell proliferation. Inhibiting these specific protein interactions prevents disease progression in cancer and lysosomal storage disorders.