Merck

Last updated January 31, 2026

124

Innovation Areas

5,362

Inventors

Collaborations

Hydroxylamine and fluorinated nucleobase synthesis: MerckRecent Research Landscape

Traditional chemical synthesis of fluorinated indanones suffers from low regioselectivity and hazardous reagents. These innovations utilize engineered enzymes to control stereospecific hydroxylation for high-purity Belzutifan production.

What technical problems is Merck addressing in Hydroxylamine and fluorinated nucleobase synthesis?

Inefficient synthetic route scalability

(12)evidences

Low stereochemical purity and yield in complex indanone and pyrrolidine precursors. Improving these metrics reduces waste and cost in pharmaceutical manufacturing.

Low fluorinated nucleoside yields

(4)evidences

Uncontrolled inflammatory signaling and viral replication cycles. Mitigating these processes prevents tissue damage and chronic disease progression.

Unstable pharmaceutical intermediate synthesis

(2)evidences

Low chemical stability during synthesis leads to degradation and poor purity profiles. Improving structural integrity during processing ensures consistent therapeutic potency.