Merck

Last updated January 31, 2026

124

Innovation Areas

5,362

Inventors

Collaborations

Perfusion-controlled host-microbe interface bioreactor: MerckRecent Research Landscape

Dilute cellular suspensions in large-scale cultivation increase processing time and energy costs. These innovations integrate concentration mechanisms directly into the reactor flow to maintain high viable cell densities.

What technical problems is Merck addressing in Perfusion-controlled host-microbe interface bioreactor?

Inaccessible real-time interface dynamics

(15)evidences

Signal drift and interference in single-use probe interfaces lead to unreliable data. Correcting these errors ensures precise control over the host-microbe environment.

Airborne and liquid contamination

(12)evidences

Inconsistent conductivity readings and manual sampling errors lead to unreliable water quality assessments. Automated, high-precision monitoring ensures real-time detection of trace contaminants.

Incomplete airborne fraction capture

(9)evidences

Loss of volatile or particulate fractions during collection leads to inaccurate environmental analysis. Capturing both aerosol and vapor phases ensures comprehensive chemical and biological profiling.

Inadequate container component integration

(1)evidences

Spatial gradients in nutrient concentration and metabolic waste create inconsistent cellular microenvironments. Eliminating these gradients ensures uniform physiological responses across the bioreactor interface.