Merck

Last updated January 31, 2026

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Protein formulation excipient selection: MerckRecent Research Landscape

High concentration biologics suffer from excessive viscosity that prevents injection and manufacturing flow. These formulations utilize specific chemical additives to disrupt intermolecular interactions and maintain syringeability.

What technical problems is Merck addressing in Protein formulation excipient selection?

High concentration protein viscosity

(4)evidences

Excessive viscosity in concentrated biological formulations prevents effective delivery and processing. Reducing this physical resistance ensures injectability and manufacturing feasibility.

Protein thermal degradation instability

(3)evidences

High-concentration protein therapeutics suffer from excessive viscosity and thermal degradation. Addressing these physical limitations allows for subcutaneous delivery and extended shelf life.