Merck

Last updated January 31, 2026

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Substituted cyclodextrin solubilization complex: MerckRecent Research Landscape

Unstable amorphous states and solvate impurities during synthesis lead to inconsistent drug potency and shelf-life. Precise control over crystalline lattice formation ensures thermodynamic stability and regulatory compliance for neuromuscular blockade reversal agents.

What technical problems is Merck addressing in Substituted cyclodextrin solubilization complex?

Poor drug solubility

(3)evidences

The synthesis of sugammadex is prone to significant impurity profiles and inefficient crystallization pathways. Improving these parameters ensures pharmaceutical-grade quality and manufacturing scalability.

Poor aqueous drug solubility

(3)evidences

Inconsistent crystalline structures lead to unpredictable solubility and poor manufacturing reproducibility. Achieving polymorphic stability ensures reliable drug performance and shelf life.