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Last updated January 21, 2026
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Substantive leave-on mucoadhesive matrices: Procter & GambleRecent Research Landscape

Engineering the residence time of active ingredients on gingival tissue via leave-on polymer networks. This creates differentiation by extending therapeutic contact beyond traditional rinse-off delivery windows.

What technical problems is Procter & Gamble addressing in Substantive leave-on mucoadhesive matrices?

Metallic ion chemical instability

(25)evidences

Tin ions in oral care formulations are prone to oxidation and precipitation, which reduces their therapeutic efficacy. Stabilizing these ions ensures prolonged bioavailability and effective treatment of dental sensitivity and plaque.

Insufficient active ingredient residence time

(10)evidences

Active ingredients in the oral cavity are rapidly washed away by saliva and swallowing. Extending contact time between the formulation and the gingival tissue is necessary to ensure therapeutic efficacy for gum health.

Inadequate gingival tissue retention

(2)evidences

Standard oral care formulations are rapidly washed away by saliva, preventing active ingredients from remaining in contact with the gums long enough to be effective. Improving residence time on mucosal surfaces ensures sustained therapeutic delivery for gum health.