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Shiseido

Last updated January 31, 2026
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12-hydroxystearic acid alpha-gel structure: ShiseidoRecent Research Landscape

Unstable emulsion structures lead to phase separation and poor sensory delivery in topical products. Engineering the 12-hydroxystearic acid network maintains a consistent alpha-crystalline gel phase to ensure formulation shelf-life.

What technical problems is Shiseido addressing in 12-hydroxystearic acid alpha-gel structure?

Poor active ingredient penetration

(2)evidences

Topical formulations often suffer from low skin penetration and rapid degradation of active compounds. Enhancing transdermal delivery through stable vesicle structures ensures effective therapeutic concentrations reach target skin layers.

Thermodynamic emulsion instability

(2)evidences

Standard lipid mixtures often suffer from phase separation or crystallization over time. Stabilizing the alpha-gel structure prevents ingredient precipitation and maintains consistent texture for skin applications.