Shiseido

Last updated January 31, 2026

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Epidermal stem cell proliferation agents: ShiseidoRecent Research Landscape

Compromised skin barrier integrity leads to chronic inflammation and moisture loss, which is mitigated by modulating stem cell signaling to accelerate cuticle regeneration. Controlling the rate of cellular differentiation ensures consistent tissue repair and product efficacy.

What technical problems is Shiseido addressing in Epidermal stem cell proliferation agents?

Impaired epidermal sensory signaling

(19)evidences

Reduced neurotransmitter release and diminished Merkel cell activity lead to compromised skin barrier repair and accelerated aging. Restoring these sensory communication pathways improves regenerative capacity and structural integrity.

Epidermal atrophy and dehydration

(14)evidences

Deteriorating skin structural integrity and slow cellular turnover. Restoring proliferative vigor prevents tissue thinning and age-related barrier dysfunction.

Tissue regenerative capacity decline

(9)evidences

Compromised cellular barriers and oxidative damage lead to tissue degradation. Restoring these protective functions prevents systemic vulnerability and chronic inflammation.