Shiseido

Last updated January 31, 2026

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Mpc1 mitochondrial pyruvate carrier inhibitors: ShiseidoRecent Research Landscape

Dermal cavitation and stem cell exhaustion lead to visible skin aging and structural looseness. These innovations suppress the MPC1 transporter to metabolicly reprogram and activate endogenous stem cell populations.

What technical problems is Shiseido addressing in Mpc1 mitochondrial pyruvate carrier inhibitors?

Impaired cutaneous sensory signaling

(27)evidences

Reduced neurotransmitter release and signaling between Merkel cells and nerve endings leads to diminished skin sensitivity and barrier dysfunction. Restoring this communication pathway reverses age-related sensory decline and skin fragility.

Excessive skin pigmentation

(17)evidences

External stressors cause structural damage and loss of moisture in the dermal layers. Preventing this breakdown maintains skin integrity and prevents premature aging.