Shiseido

Last updated January 31, 2026

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Percutaneous absorption enhancer chemistry: ShiseidoRecent Research Landscape

Poor molecular absorption limits the efficacy of topical treatments, leading to wasted active ingredients. This technology engineers the hyaluronate structure to facilitate deeper skin penetration and improve bioavailability.

What technical problems is Shiseido addressing in Percutaneous absorption enhancer chemistry?

Insufficient dermal barrier permeability

(8)evidences

The stratum corneum naturally restricts the entry of active cosmetic ingredients. Overcoming this barrier allows for effective delivery of topically applied compounds to deeper skin layers.

Low active ingredient stability

(4)evidences

Low skin permeability and rapid degradation of bioactive compounds limit topical efficacy. Enhancing percutaneous absorption ensures therapeutic concentrations reach target dermal layers.