Shiseido

Last updated January 31, 2026

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Raldh2 expression enhancing agents: ShiseidoRecent Research Landscape

Leaky gut syndrome compromises systemic health and increases inflammatory risks. These compositions engineer the tight junction protein network to restore epithelial barrier resistance.

What technical problems is Shiseido addressing in Raldh2 expression enhancing agents?

Impaired epidermal sensory signaling

(17)evidences

Diminished neurotransmitter release from Merkel cells leads to reduced skin barrier maintenance and accelerated tissue aging. Restoring this signaling pathway improves regenerative capacity and structural integrity.

Impaired tissue regenerative capacity

(9)evidences

Weakened mucosal integrity and oxidative stress in the gut lead to systemic inflammation. Restoring barrier function prevents pathogen translocation and chronic immune activation.