Shiseido

Last updated January 31, 2026

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Topical formulation matrix chemistry: ShiseidoRecent Research Landscape

Unstable active concentrations in topical applications lead to poor skin penetration and reduced efficacy. Precise titration of niacinamide within the chemical matrix ensures consistent bioavailability and shelf stability.

What technical problems is Shiseido addressing in Topical formulation matrix chemistry?

Insufficient dermal barrier permeability

(20)evidences

The stratum corneum naturally restricts the entry of active compounds into deeper skin layers. Overcoming this physical resistance is necessary to achieve therapeutic or aesthetic efficacy.

Excessive formulation stringiness

(14)evidences

High molecular weight compounds like hyaluronate face significant barriers to crossing the stratum corneum. Overcoming this transport limitation ensures active ingredients reach deeper cutaneous layers for therapeutic effect.