Volatile compounds like nicotine suffer from premature evaporation and inconsistent delivery kinetics. Stabilizing the release rate prevents dosage fluctuations and sensory degradation.

Chemical instability and harsh synthetic agents cause damage to sensitive mucosal and dermal surfaces. Reducing these adverse reactions improves safety and biocompatibility in topical applications.

Topical and injectable formulations often cause localized tissue discomfort or inflammatory responses upon application. Reducing these adverse sensations improves patient compliance and safety.