Low bioavailability of active compounds due to the skin's natural protective layers. Overcoming this resistance ensures therapeutic concentrations reach target dermal tissues.

Compromised epidermal integrity leads to chronic inflammation and moisture loss. Restoring this barrier prevents environmental hypersensitivity and pathological dryness.

Lipid-based systems suffer from rapid oxidation and rancidity which limits product shelf life. Preventing this degradation maintains chemical integrity and functional potency.