Low olfactory threshold and weak binding affinity in synthetic sandalwood substitutes. Increasing molecular rigidity through cyclopropanation overcomes poor receptor activation and low scent longevity.

Fragrance molecules like ambergris and sandalwood analogs often suffer from rapid oxidative degradation or volatility issues. Improving chemical stability ensures longer-lasting scent profiles and shelf-life in commercial formulations.

Low olfactory detection thresholds in traditional sandalwood synthetics limit commercial viability. Increasing molecular potency reduces the required concentration for fragrance impact.