Syngenta

Last updated January 31, 2026

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Cas exonuclease fusion proteins: SyngentaRecent Research Landscape

Random genomic integration leads to unpredictable phenotypes and low breeding efficiency, which is mitigated by engineering site-specific cleavage and inversion mechanisms. Precise control over insertion sites ensures stable trait expression and reduces the cost of screening non-viable cell lines.

What technical problems is Syngenta addressing in Cas exonuclease fusion proteins?

Inadequate transgene expression stability

(14)evidences

Inefficient incorporation of exogenous DNA at precise genomic locations. Increasing integration rates enables predictable genetic modification without extensive cell screening.

Inefficient maternal genome elimination

(10)evidences

Natural rates of haploid embryo formation are insufficient for rapid crop breeding. Overcoming this limitation accelerates the development of homozygous lines.

Inefficient multi-trait genetic modification

(6)evidences

Traditional methods for creating homozygous lines in dicots and rice are time-consuming and labor-intensive. Integrating genome editing with haploid induction bypasses multiple generations of backcrossing.

Low plant transformation efficiency

(6)evidences

Recalcitrance to genetic modification in specific crop species prevents efficient trait development. Overcoming this bottleneck accelerates the production of stable transgenic lines.