Uncontrolled substitution patterns during the synthesis of complex cyanocyclopropyl and oxazolidinone derivatives lead to poor isomeric purity. Achieving precise site-specific modification prevents yield loss and costly separation of structural isomers.

Uncontrolled racemization and poor stereochemical integrity during the formation of complex sulfur-containing heterocycles. Achieving high enantiopurity in sulfoximines is critical for bioactivity and molecular recognition in medicinal chemistry.