Agricultural yield loss and plant destruction caused by harmful organisms. Mitigating this damage ensures food security and prevents economic loss in commercial farming.

Existing chemical agents fail to mitigate damage from resistant or evolving agricultural pests. Improving efficacy against these organisms prevents significant yield loss and economic instability.

Existing chemical controls suffer from declining efficacy due to evolving biological resistance. Developing novel scaffolds overcomes metabolic detoxification mechanisms in target organisms.

Insects, nematodes, and parasites cause significant yield loss and degradation of plant propagation material. Mitigating these biological threats prevents economic loss and ensures food security.