Existing herbicidal scaffolds often fail to target a broad enough range of invasive plant species. Expanding the chemical diversity of imidazole derivatives overcomes resistance and increases efficacy across diverse weed populations.

Existing herbicidal scaffolds suffer from insufficient potency or narrow spectrums of activity against resistant weed species. Enhancing molecular binding to target sites overcomes chemical resistance and improves crop yields.

Existing herbicidal scaffolds fail to control diverse or resistant weed populations. Expanding the chemical space addresses the limitation of narrow efficacy ranges and declining potency.